Abstract
Ultrasmall superparamagnetic iron oxide (USPIO) particles are very useful for cellularmagnetic resonance imaging (MRI), which plays a key role in developing successful stemcell therapies. However, their low intracellular labeling efficiency, and biosafety concernsassociated with their use, have limited their potential usage. In this study we develop anovel system composed of RBC-derived vesicles (RDVs) for efficient delivery of USPIOparticles into human bone marrow mesenchymal stem cells (MSCs) for cellular MRI invitro and in vivo. RDVs are highly biosafe to their autologous MSCs as manifested by cellviability, differentiation, and gene microarray assays. The data demonstrate thepotential of RDVs as intracellular delivery vehicles for biomedical applications.
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