Abstract
The reactivity of copper(II) acetate as catalyst in a standard C O coupling reaction has been systematically evaluated. Optimization of the reaction conditions resulted in a protocol involving stoichiometric amounts of reagents, a substoichiometric amount of base and 20 mol% catalyst, at 50 °C in 1,2-dichloroethane and under 1 atm O 2. Next, the reactivity of polymer-supported copper(II) acetate was evaluated. Although it is found that, in contrast to previous results obtained in related C N coupling reactions, the polymer-supported catalyst is in this case less efficient than the corresponding homogeneous one, the catalyst turns out to be conveniently recovered from the reaction mixture by simple filtration.
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