Homocysteine level is positively and independently associated with serum creatinine and urea nitrogen levels in old male patients with hypertension

Qianhong Yang,Xi Zhang,Youwei Lu,Jiayi Xu,Yanhua Deng

doi:10.1038/s41598-020-75073-x

Abstract

A cross-sectional study to show whether and how serum fasting homocysteine levels are associated with renal function changes in patients with hypertension. Homocysteine levels were associated with serum creatinine and blood urea nitrogen (BUN) levels with coefficients of 2.04 and 0.07, respectively, only in males and independent of confounders. In addition, low density lipoprotein cholesterol (LDL-C) levels were positively and left ventricular ejection fraction (LVEF) was negatively associated with serum creatinine level in males; age was positively associated with serum creatinine levels in females. Age was a common risk factor positively associated with BUN levels in both sexes, while total cholesterol (TC) levels and glycemic control were independent risk factors that were positively associated with BUN levels only in males. LDL-C levels and LVEF were negatively associated with BUN levels in females. Body mass index (BMI) was positively associated and hemoglobin A1c (HbA1c) levels, high density lipoprotein cholesterol (HDL-C) levels and the presence of stroke were negatively associated with serum uric acid levels in male patients. In contrast, only LVEF was positively associated with uric acid levels in females. In conclusion, homocysteine level is an independent risk factor associated with serum creatinine and BUN levels in male patients with hypertension.

Highlights

A cross-sectional study to show whether and how serum fasting homocysteine levels are associated with renal function changes in patients with hypertension
Observational studies have shown that hyperhomocysteinemia is associated with the risk of developing chronic kidney disease (CKD) and albuminuria in the general p opulation[5,14,15,16,17], reports showed that elevated serum homocysteine levels are not correlated with serum uric acid levels in patients with g out[18]
Only 13.4% of males and 7.3% of females were diagnosed with CKD and the average serum creatinine, blood urea nitrogen (BUN) and uric acid levels were in the normal ranges, their renal function adjoined to the upper limits

Summary

Introduction

A cross-sectional study to show whether and how serum fasting homocysteine levels are associated with renal function changes in patients with hypertension. Homocysteine level is an independent risk factor associated with serum creatinine and BUN levels in male patients with hypertension. The hypothesis focused on homocysteine toxicity can be summarized as homocysteinylation (protein structure modifications); oxidative stress induction; and e xcitotoxicity[1]. Observational studies have shown that hyperhomocysteinemia is associated with the risk of developing CKD and albuminuria in the general p opulation[5,14,15,16,17], reports showed that elevated serum homocysteine levels are not correlated with serum uric acid levels in patients with g out[18]

Methods

Results

Conclusion