Abstract
To the Editor: We read with great interest the article by Ay et al1 on the role of homocysteine in stroke and thromboembolic complications in patients with atrial fibrillation. Certainly, homocysteine has previously been shown to be associated with an increased risk of stroke,2,3 thrombosis,4 and impaired fibrinolysis5; it is therefore important that its association with atrial fibrillation and the risk of left atrial thrombus and subsequent strokes be clarified. Nonetheless, we have issues with certain aspects of the study by Ay et al.1 First, the numbers in groups studied are small (22 and 20, respectively). We agree that recruiting …
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