Homochlorcyclizine: An antiallergic drug with multiple clinical properties

Abstract

1. 1. N-p-chloro-benzhydryl-N'-methyl-homopiperazine dihydrochloride is a drug possessing a wide range of clinical effect and is useful in certain types of asthma and allergic cough and resistant cases of seasonal and perennial allergic rhinitis, urticaria, dermatitis, and some other allergic and allergic-like manifestations. 2. 2. Its clinical effectiveness cannot be satisfactorily explained by its known antagonism to histamine, acetylcholine, or serotonin or by simple bronchodilator action. It is possible that its action concerns antagonism against the slow-reacting substance or other known or unknown muscle-contracting or capillary permeability factors.