Abstract
Pig and human spleens produce large numbers of lymphocytes and plasma cells (1,2). Many newly formed lymphocytes leave the spleen and home to different lymphoid and non-lymphoid organs (1). In mice the spleen was essential in producing memory cells for antibody production in the bone marrow after a booster injection (3). In the present study a technique for selective labeling of the pig spleen was used to study the fate of spleen-derived lymphocytes in other organs, to classify the emigrants and to localize them in lymphoid organs 1 to 4 d. after labeling the spleen exclusively. In a second experiment the rate of splenic lymphocyte production and immigration of newly formed lymphocytes was studied after a secondary response to i.v. sheep red blood cells.
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