Abstract
BETWEEN 3 and 6 days after antigenic stimulation, lymph nodes discharge large numbers of basophilic blast cells (immunoblasts) into the efferent lymph which carries them to the blood1–3. These cells contain many polyribosomes but little endoplasmic reticulum; nevertheless, they produce specific antibody1,4,5 and are specifically cytotoxic in vitro6. Unlike small lymphocytes they incorporate DNA precursors with avidity and some of them transform into true plasma cells in vivo7. Immunoblasts produced by the caudal lymph nodes of rats can be obtained by collecting the thoracic duct lymph 3–6 days after antigenic stimulation of the hindquarter regions8,9.
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