Abstract
All homoiothermic organisms are capable of maintaining a stable body temperature using various negative feedback mechanisms. However, current models cannot satisfactorily describe the thermal adaptation of homoiothermic living systems in a physiologically meaningful way. Previously, we introduced stress entropic load, a novel variable designed to quantify adaptation costs, i.e. the stress of the organism, using a thermodynamic approach. In this study, we use stress entropic load as a starting point for the construction of a novel dynamical model of human thermoregulation. This model exhibits bi-stable mechanisms, a physiologically plausible features which has thus far not been demonstrated using a mathematical model. This finding allows us to predict critical points at which a living system, in this case a human body, may proceed towards two stabilities, only one of which is compatible with being alive. In the future, this may allow us to quantify not only the direction but rather the extent of therapeutic intervention in critical care patients.
Highlights
All homoiothermic organisms are capable of maintaining a stable body temperature using various negative feedback mechanisms
We introduced stress entropic load (SEL), a novel variable designed to facilitate the objective physical measurement of the stress load of a living body by monitoring energy and matter flows in the body using the proxy of entropy production[8]
We propose a novel model of human thermoregulation using the concept of stress entropic load as a departure point
Summary
All homoiothermic organisms are capable of maintaining a stable body temperature using various negative feedback mechanisms. We use stress entropic load as a starting point for the construction of a novel dynamical model of human thermoregulation This model exhibits bi-stable mechanisms, a physiologically plausible features which has far not been demonstrated using a mathematical model. A large number of physiologically plausible models[4,5] have attempted to conceptualize homeostatic mechanisms using a systemic approach based on regulated variables, their set points, errors, and comparative information and their proxies This is an extremely problematic approach, as there are countless physiological parameters that characterize the living organism at a given moment, and these countless parameters can further involve countless synergies or antagonisms. As the calculation itself is based on Scientific Reports | (2021) 11:17327
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