Homeostatic model assessment of β-cell function may be an emerging predictor of bone resorption in metabolically unhealthy obesity

Abstract

Objectives: The aim of this study is to compare three distinct bone markers in metabolically healthy and unhealthy obese and non-obese subjects, according to various metabolic health criteria.
 Methods: The study enrolled a total of 35 subjects, including 11 healthy normal-weight and 23 obese subjects. Based on HOMA-Beta, all participants were divided into three groups: normal weight (HOM-Beta<100%, n=11), obese (HOMA-Beta <100%, n=12), and obese (HOMA-Beta >100%, n=12). The serum levels of osteocalcin, procollagen I amino-terminal propeptide (P1NP), and beta-cross Laps as bone turnover markers, as well as serum levels of 25 (OH) vitamin D3, and PTH were analyzed.
 Results: Significant differences were observed in BMI, age, 25(OH)D3, FBS, Insulin, HOMAIR, and HOMA-Beta among the groups. Analysis of bone markers revealed that the serum levels of Beta-cross Laps, P1NP, and osteocalcin were significantly different among all studied groups categorized by the HOMA-Beta model. In this context, circulating levels of osteocalcin and Betacross Laps in the normal weight group (HOMA-Beta<100%) were significantly higher than the obese group (HOMA-Beta <100%). In obese patients with HOMA-Beta <100%, Beta-cross Laps and P1NP levels were lower compared to the obese group with HOMA-Beta >100%.
 Conclusion: The data suggests that HOMA-Beta, as an index of β-cell function, can be used in part of metabolically healthy obese (MHO) criteria and bone remodeling is altered in the context of metabolically healthy obesity.