Home-based Aerobic Exercise and Resistance Training in Peritoneal Dialysis Patients: A Randomized Controlled Trial

Kiyotaka Uchiyama,Kentaro Yamaki,Naoki Washida,Shu Wakino,Takahiro Kasai,Kaori Muraoka,Kohkichi Morimoto,Hiroshi Itoh,Kazutoshi Miyashita

doi:10.1038/s41598-019-39074-9

Kiyotaka Uchiyama, Kentaro Yamaki + Show 7 more

Open Access

https://doi.org/10.1038/s41598-019-39074-9

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Abstract

Potential effects of aerobic and resistance training in peritoneal dialysis (PD) patients have been partially elucidated. We investigated effects of a home-based exercise program on physical functioning and health-related quality of life (HRQOL) in PD patients. Patients were randomly assigned to exercise (n = 24) and usual care (n = 23) groups. The exercise patients performed aerobic exercise thrice weekly and resistance training twice weekly at home for 12 weeks. The usual care patients received no specific intervention. The distance in incremental shuttle walking test significantly improved in the exercise group compared with the usual care group (P = 0.02). Among the HRQOL subscales assessed using the Kidney Disease Quality of Life-Short Form questionnaire, kidney disease component summary (P = 0.03), physical role functioning (P = 0.01), emotional role functioning (P < 0.01), and role/social component summary (P < 0.01) significantly improved in the exercise group. Moreover, serum albumin was significantly maintained in the exercise group (P = 0.03). There were no reported adverse events associated with the intervention. To our knowledge, this is the first randomized controlled trial to indicate the beneficial effects of a 12-week home-based exercise program exclusively in PD patients.

Highlights

Among the domains in 36-Item Short Form Health Survey (SF-36), physical role functioning, emotional role functioning, and role/ social component summary (RCS) significantly improved (P = 0.01, P = 0.005, and P < 0.01, respectively) and bodily pain tended to improve (P = 0.07) in the exercise group when compared with the findings in the usual care group
Serum albumin was significantly maintained (P = 0.02) and high-density lipoprotein (HDL) cholesterol tended to improve (P = 0.07) in the exercise group when compared with the findings in the usual care group
We noted improvements in aerobic capacity assessed with the incremental shuttle walking test (ISWT), several domains of health-related quality of life (HRQOL), and the serum albumin level in the exercise group when compared with the findings in the usual care group

Summary

Introduction

There were no significant differences in the incremental shuttle walking test (ISWT) (P = 0.83), handgrip strength (P = 0.91), and quadriceps strength (P = 0.43) between the exercise and usual care groups. The ISWT significantly improved (P = 0.02) in the exercise group when compared with the finding in the usual care group.

Results

Conclusion