Home Oral Care of Periodontal Patients Using Antimicrobial Gel with Postbiotics, Lactoferrin, and Aloe Barbadensis Leaf Juice Powder vs. Conventional Chlorhexidine Gel: A Split-Mouth Randomized Clinical Trial.

Andrea Butera,Damiano Taccardi,Maurizio Pascadopoli,Andrea Scribante,Simone Gallo

doi:10.3390/antibiotics11010118

Abstract

Periodontitis is a progressive destruction of both soft and hard tooth-supporting tissues. In the last years, probiotics have been proposed as a support to the gold standard treatment scaling and root planing (SRP), but no extensive literature is present as regards the effect of the more recent postbiotics. Thirty patients subjected to SRP were randomly assigned to two domiciliary hygiene treatments based on the following oral gels: the postbiotics-based Biorepair Parodontgel Intensive (Group 1) and the chlorhexidine-based Curasept Periodontal Gel (Group 2). At baseline (T0) and after 3 and 6 months (T1–T2), the following periodontal clinical parameters were recorded: Probing Pocket Depth (PPD), recession, dental mobility, Bleeding on Probing (BoP), and Plaque Control Record (PCR). A significant intragroup reduction was assessed in both groups for PPD, BoP, and PCR; conversely, recession significantly increased in both groups, whereas dental mobility did not vary. As regards intergroup comparisons, no statistically significant differences were assessed. Both gels, respectively, containing antioxidant natural ingredients and chlorhexidine, are effective for the domiciliary treatment of periodontitis. Further studies are required to evaluate the singular chemical compounds of the gels expected to exert the beneficial action assessed in this preliminary study.

Highlights

Periodontitis is an inflammatory condition that involves both soft and hard toothsupporting tissues and constitutes the major cause of tooth loss after dental decay
The factors mostly related with periodontal disease are smoking [3], the alteration of leukocytes [4], immunosuppression [5], diabetes [5], and genetic polymorphisms of genes related to the production of inflammatory cytokines [6]
Symbiotic bacteria are able to induce a modulation of the local environment in order to allow scaling and root planing (SRP) to be efficient [26]

Summary

Introduction

Periodontitis is an inflammatory condition that involves both soft and hard toothsupporting tissues and constitutes the major cause of tooth loss after dental decay. This process is the result of an untreated gingival inflammation linked to bacterial plaque accumulation. The factors mostly related with periodontal disease are smoking [3], the alteration of leukocytes [4], immunosuppression [5], diabetes [5], and genetic polymorphisms of genes related to the production of inflammatory cytokines [6]. Bacterial plaque accumulation is the most important risk factor, since specific bacteria, called

Methods

Discussion

Conclusion