Abstract
Essential oil of Homalomena pineodora inhibits diabetic pathogens; however, the activity was not sustainable when applied as wound dressing. This study aims to synthesise the essential oil nanoparticle using chitosan. The nanoparticles were synthesised with ion gelation method, confirmed by spectroscopic analysis. The spherical nanoparticles display a size of 70 nm, with strong surface charge of +24.10 mV. The nanoparticles showed an initial burst release followed by a slow release pattern for 72 h, following the first order of kinetic. The release behaviour was ideal for wound dressing. The antimicrobial activity was broad spectrum. The formation of nanoparticle enhanced the antimicrobial efficacy of the essential oil. The nanoparticle also showed a concentration-dependent killing behaviour on time–kill assay. In the 3D collagen wound models, the nanoparticles reduced the microbial growth by 60–80%. In conclusion, H. pineodora nanoparticles showed pharmaceutical potential in inhibiting microbial growth on diabetic ulcers.
Highlights
Essential oil of Homalomena pineodora inhibits diabetic pathogens; the activity was not sustainable when applied as wound dressing
We have reported that H. pineodora essential oil exhibited excellent bactericidal activity on diabetic wound pathogens[6]
This study focused on the characterisation and antimicrobial efficiency of H. pineodora essential oil nanoparticles (EoNPs) using chitosan as encapsulant material
Summary
Essential oil of Homalomena pineodora inhibits diabetic pathogens; the activity was not sustainable when applied as wound dressing. H. pineodora nanoparticles showed pharmaceutical potential in inhibiting microbial growth on diabetic ulcers. Various types of antimicrobial agent, nanoparticles and natural products have been incorporated into wound dressing. The incorporation of the heavy metals into a wound dressing, has been reported to cause skin allergy and inhibit fibroblast growth[3]. We have reported that H. pineodora essential oil exhibited excellent bactericidal activity on diabetic wound pathogens[6]. This study focused on the characterisation and antimicrobial efficiency of H. pineodora essential oil nanoparticles (EoNPs) using chitosan as encapsulant material. The synthesized nanoparticles can be incorporated into wound dressing material, in order to improve the antimicrobial performance and sustain the antimicrobial activity[5]. H. pineodora leaves were collected from a plant nursery in the Universiti Sains
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