Abstract
At the risk of upsetting some people I’m going to say it: I love a holy grail. I am a fan of Arthurian legend and so a mention of the holy grail evokes memories of knights in shining armor, Merlin the wizard, and Excalibur, the sword that King Arthur, as rightful heir to the throne of England, pulls out of a stone. I say that I risk upsetting some people because the use of the “holy grail” phrase in the scientific literature and science journalism has been very contentious over the years and was even been banned here in C&EN by one of my predecessors in 2003. I’m breaking the ban, but I have a good reason: Accounts of Chemical Research, the ACS journal that published one of the most talked-about holy grail papers back in 1995, is issuing a special issue to commemorate the 50th anniversary of the journal.
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