Abstract
Holmes Tremor due to Artery of Percheron Infarct: Clinical Case and Treatment Using Deep Brain Stimulation of the Vim and ZI Targets
Highlights
Holmes tremor (HT) is characterized as a 3–4-Hz flexor-extension oscillation and was initially described by Gordon Holmes in 1904 as a tremor that is present at rest, exacerbated with posture, and further intensified with movement.[1]
Cases of HT have been reported to respond to levodopa[7] and to deep brain stimulation (DBS) of several nuclei and structures, including the bilateral thalami,[5] ventral Ventral intermediate nucleus (Vim),[8] subthalamic nucleus (STN), globus pallidus interna (GPi),[2] and prelemniscal radiations (Raprl).[9]
zona incerta (ZI) has been targeted in treatment of more proximal tremors by overriding oscillations of the interpositus nucleus (IO) and medial reticular formation (MRF)
Summary
Holmes Tremor due to Artery of Percheron Infarct: Clinical Case and Treatment Using Deep Brain Stimulation of the Vim and ZI Targets. O’Shea1,2*, Mitchell Elkind[2,3], Seth L. Pullman2 & Blair Ford2 1Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA, 2Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA, 3Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
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