Abstract
Mesoporous carbon nanoparticles (NPs) are widely used to construct nano-theranostic systems due to their excellent physicochemical properties. Herein, we introduce these mesoporous NPs as nanocarriers to build self-propelled transport systems. Such nanocarriers are successfully fabricated by depositing Pt NPs onto the half-sphere surface. Compared with conventional silica-based nanomotors, hollow mesoporous carbon nanospheres (HMCNs) based nanomotors can achieve a high loading efficiency (1370 mg/g) of anticancer drug doxorubicin hydrochloride (DOX) due to its hydrophobic nature. The enhanced motion is observed by introducing the NIR-light irradiation due to the local thermophoresis from the upward temperature of HMCNs and also observed by introducing H2O2 that drives the HMCNs@Pt by the asymmetric decomposition. Interestingly, such enhanced motion also results in the increase of the amount of HMCNs adhering to the surface of living cancer cells, which is beneficial for enhancing the efficiency of drug delivery. This synergetic carbon-based transport system with high cargo loading capacity and dual actuated autonomous motion ability displays immense potential for further functional “smart” devices.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.