Abstract
Implants that simultaneously act as osteoconductive grafts and as devices for local drug delivery could provide an attractive system for bone regeneration and repair. In this work, we prepared hollow calcium silicate microspheres with open holes using a solid-in-oil-in-water (S/O/W) emulsion method, and the microspheres were modified with simulated body fluid (SBF) to introduce a micro-porous structure. We further studied the protein adsorption and release profile of two different model proteins, bovine serum albumin (BSA) and lysozyme (LSZ), for two kinds of microstructured microspheres. The SBF-modified microspheres adsorbed greater amounts of BSA and LSZ compared with pure calcium silicate microspheres, and the absorbed amount of BSA was greater than that of LSZ. The protein release profile was dependent on the initial protein loading and the microstructure of the microsphere. The results indicate that the hollow calcium silicate microspheres have significant potential as osteoconductive devices for local drug or growth factor delivery in bone regeneration.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
