Abstract
We report holistic quantification of cutaneous microcirculation with spatial frequency domain imaging (SFDI) and coherent hemodynamics spectroscopy (CHS) based on a dynamic microcirculation PIPE model. A simple device was developed to induce periodic variations in cutaneous blood volume and flow velocity. Both baseline and dynamic features of cutaneous microcirculation for healthy subjects were completely quantified. The CHS findings were further related to SSMD-SFDI imaging of the same healthy subjects under reactive hyperemia protocol. The results demonstrate spatial frequency domain imaging and coherent hemodynamics spectroscopy based on the dynamic microcirculation PIPE model provides a valuable tool for functional studies with hemodynamic-based techniques.
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