HOGG1 and APE1 Gene Polymorphism and Risk of Gastrointestinal Cancer in Rural Population of South-Western Maharashtra

Abstract

The base excision repair (BER) mechanism plays a key role in repair of DNA modifications caused by oxidized or reduced bases which help in maintaining the genomic stability. Genetic variations in BER pathway genes are known to alter the DNA repair capacity, thereby appealing the susceptibility to various cancer risks. Present study was undertaken to evaluate an association between the polymorphisms in hOGG1 and APE1 genes and the susceptibility of gastrointestinal cancer in unexplored population of south-western Maharashtra. In this hospital-based case-control study, we used polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) method to examine the genotype distribution of hOGG1 (rs1052133) and APE1 (rs1130409) genes in 200 GI cancer patients in comparison with 200 healthy controls. Results of our investigations revealed no direct significant association between the variant genotype of hOGG1 (OR: 0.99; CI: 0.55-1.78; p: 0.99) and GI cancer risk when compared with the wild type genotype while variant genotype of APE1 (OR: 0.31; CI: 0.12-0.82; p: 0.014) showed a decreased risk for susceptibility of GI cancer. Thus, our study indicated that the polymorphism in APE1gene may contribute to the protective effect of GI cancer development among rural population of the south-western Maharashtra.