Abstract
Hypothyrodisim associated with different neuromuscular manifestations. Rarely patient with hypothyroidism may develop muscular pseudohypertrophy a condition called Hoffmann’s syndrome in adults. We report a patient present mainly with myelgia, cramps, calf pseudohypertrophy and persistently elevated Creatine Kinase (CK) with absence of other systemic symptoms of hypothyroidism. His laboratory works revealed severe hypothyroidism. Treatment with L-thyroxine resulted into disappearance of symptoms, normalization of CK and return of calf size to normal. Hypothyrodism should be considered when evaluating patients with neuromuscular complaints even in absence of systemic symptoms.
Highlights
Hypothrodism is one of the most prevalent endocrine disorders
Hypothyroid myopathy may associate with muscular pseudohypertrophy a condition called Hoffmann syndrome in adults and Kocher-Debre-Semelaigane syndromes in children
We report a case of hypothyroidism presented solely with myopathic feature and calf pseudohypertrophy in absence of other systemic symptoms with resolution of symptoms with L-thyroxine treatment
Summary
Hypothrodism is one of the most prevalent endocrine disorders. Different neuromusclualr complications can develop with hypothyrodism. Nonspecific neuromuscular complaints like myelgia, muscle cramps and mild elevation of Creatine Kinase (CK) are the most common myopathic features related to hypothyroidism. Other myopathic features included proximal muscle weakness and myoedema. Hypothyroid myopathy may associate with muscular pseudohypertrophy a condition called Hoffmann syndrome in adults and Kocher-Debre-Semelaigane syndromes in children. We report a case of hypothyroidism presented solely with myopathic feature and calf pseudohypertrophy in absence of other systemic symptoms with resolution of symptoms with L-thyroxine treatment
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