Abstract
IntroductionParaneoplastic neuropathies are rare. They are often difficult to diagnose, especially when they precede the diagnosis of cancer. Hodgkin's lymphoma is associated with multiple paraneoplastic neurological syndromes, of which demyelinating polyneuropathies are very unusual. Association with chronic inflammatory demyelinating polyneuropathy is even more uncommon.Case presentationWe report the rare case of a 74-year-old Caucasian man who presented with a complex neurological syndrome and was eventually diagnosed with the nodular sclerosing variant of Hodgkin's lymphoma. With timely diagnosis and early institution of treatment of the underlying malignancy, our patient began to show gradual improvement of his symptoms.ConclusionHodgkin's lymphoma is associated with several paraneoplastic neurological syndromes. Sometimes it can be the only presenting feature of an underlying Hodgkin's lymphoma, posing a diagnostic challenge. Prompt oncologic treatment and immunotherapy can be beneficial if instituted early in the course of the disease.
Highlights
Case presentation: We report the rare case of a 74-year-old Caucasian man who presented with a complex neurological syndrome and was eventually diagnosed with the nodular sclerosing variant of Hodgkin's lymphoma
Hodgkin's lymphoma is associated with several paraneoplastic neurological syndromes
Association with chronic inflammatory demyelinating polyneuropathy (CIDP) is very rare. Sometimes it can be the only presenting feature of an underlying Hodgkin’s lymphoma, posing a diagnostic challenge. We present one such rare case of a 74-year-old Caucasian man who presented with a complex neurological syndrome and was eventually diagnosed with nodular sclerosing Hodgkin’s lymphoma
Summary
Hodgkin's lymphoma is associated with multiple paraneoplastic neurological syndromes, of which CIDP is very uncommon. Sometimes, this can be the only presenting symptom of an underlying Hodgkin’s lymphoma, posing a diagnostic dilemma. Consent Written informed consent was obtained from the patient for publication of this case report and accompanying images. Authors’ contributions All authors had access to the data and contributed to the content of the case report. NA and SC wrote the manuscript and EB mentored and supervised the entire case writing. All authors read and approved the final manuscript. Author details 1Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY 13326, USA. Author details 1Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY 13326, USA. 2Division of Hematology and Oncology, Bassett Medical Center, Cooperstown, NY 13326, USA
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