Hodgkin's disease in adults: the royal medical services experience

Abstract

Background: The aim of this study to examine our experience in the presentation and management and to determine the factors that potentially influenced the outcome in 96 patients with Hodgkin’s lymphoma. Methods: A retrospective study done at oncology unit in royal medical services hospitals, a total 96 patient whom diagnosed with Hodgkin’s lymphoma between 2005 and 2013, data include age, sex of patients, presenting and duration of symptoms, staging of disease, and prognosis of disease. Results: 66 males and 30 females, the most common enlarged lymph node was at cervical region. The most common histopathology subtype was nodular sclerosis. Most of our patients were staged as stage 4. Systemic symptoms developed in 50 (52%) patients. The most common site of extralymphatic involvement was lung. Complete remission was noted in all 29 patients whom presented with early stages of disease and less in advanced stages. Failure of remission post treatment was noticed more in mixed cellularity and lymphocyte rich subtypes. On regular follow up of patients 8 patients whom were in complete remission developed relapse of disease; mean time of relapse was 9 months post remission. Conclusion: Hodgkin’s lymphoma has high rates of cure. Epidemiological, clinical, histological and therapeutic results in our series are similar to those Western series. Long term evaluation is necessary to assess relapse and late toxicity treatment.