HnRNP K expression and its clinical significance in human lung cancer tissues.

Abstract

There is no any specific criterion in early diagnosis of lung cancer yet. The aim of this study is to determine hnRNP K expression in lung cancer tissues and normal lung tissues and to provide data for the diagnosis and treatment of lung cancer. The expression of hnRNP K was studied by using the SP method of immunohistochemistry in lung tissue samples of 70 cases of lung cancer and 27 cases of control groups. The positive rate of hnRNP K was 64.9% (76/117) in lung cancer tissues , which was significantly higher than that in control group (33.3%, 9/27) (P <0.001) . hnRNP K was localized in the cytoplasm and/or nucleus. Three subtypes of lung cancer all showed positive staining of hnRNP K protein. The positive rate of hnRNP Kwas 73.7% (14/19) in SCLC and 54.9% (28/51) in NSCLC (P >0.05) . hnRNP K can highly express in lung cancer tissues, but it does not correlate with histological classification of lung cancer.