Abstract
Following paracetamol overdosage, hæmodialysis removes the drug at a clearance-rate similar to that of creatinine. The plasma half-life of paracetamol is considerably reduced by hæmodialysis, especially in patients with high initial plasma concentrations and hepatic damage. It is not known whether the quicker removal of the drug improves the prognosis, but the survival of one patient with a very high initial plasma concentration is a hopeful pointer. Pending a controlled evaluation of hæmodialysis it would appear reasonable to use this form of treatment, where it can be applied swiftly and safely, for patients seen within 12 hours of ingesting at least 15 g. of paracetamol, provided the history can be corroborated by estimation of plasma-paracetamol levels.
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