Abstract

List of contributors. Preface. Stefano Bellosta, Rodolpho Paoletti, Alberto Corsini: History and development of HMG-CoA reductase inhibitors. Margaret E. Brousseau and Ernst J. Schafer: Structure and mechanisms of action of HMG-CoA reductase inhibitors. Joerg Kotzka, Wilhelm Krone and Dirk Muller-Wieland: Sterol-regulatory element binding proteins (SREBPs): gene regulatory target of statin action. Gerd Schmitz and Michael Torzewski: Cellular effects of HMG-CoA reductase inhibitors on blood cells (monocytes, macrophages, platelets). Koichi Node and James K. Liao: Effects of HMG-CoA reductase inhibitors on cells of the vascular wall - pleiotropic effects of HMG-CoA reductase inhibitors. Hans-Peter Thomas and Elisabeth Steinhagen-Thiessen: Indications and contraindications for statin treatment (primary and secondary prevention of hypercholesterolemia). Helena K. Gylling and Tatu A. Miettinen: Clinical experience: studies with HMG-CoA reductase inhibitors. C. Berry, A. Davie and J. McMurray: Cost-effectiveness of statins in primary and secondary prevention of coronary heart disease. Index

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