HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells

Abstract

(Molecular Cell 77, 384–394.e1–e4; January 16, 2020) The authors report two minor errors in Figure 3G of the originally published article. In this panel, there appeared a letter “E” that was not relevant to the figure and may have been confusing to readers. Also, in the same panel, the authors report having inadvertently copied an older version of the bar graph, with fewer replicates, which is different from the one provided to reviewers in the revised version of the manuscript. These errors were made during the generation of high-resolution images toward the end of the production process and have since been corrected online. The errors do not change the message of the figure, nor do they impact the overall conclusions of the article. The authors apologize for any inconvenience.Figure 3GHMCES Deficiency Leads to a Defect in CSR in the CH12 B Cell Line (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B CellsShukla et al.Molecular CellDecember 2, 2019In BriefHMCES (5hmC binding, embryonic stem cell-specific protein), originally found to bind 5-hydroxymethylcytosine (5hmC), was recently reported to covalently crosslink to DNA at abasic sites. Shukla et al. show that HMCES specifically enables DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway during class switch recombination (CSR) in B cells. Full-Text PDF Open Archive