Abstract
Cervical cancer is the second most common cancer in women. HLA class I and II alleles polymorphisms have been shown to associate with cervical cancer risk, but results varied among different populations. In this study, the HLA-A, -B, and -DRB1 alleles among 100 southern Chinese women with cervical squamous cell carcinoma (SCC) were compared to 254 controls. Our results showed that B*51:01:02 allele frequency was significantly higher in patients with SCC than that in healthy controls (P = 3.17x 10-5, Pc = 0.005, OR = 26.68). Statistical analysis also revealed a significantly decreased frequency of B*51:01:01 (P = 7.01x 10-4, Pc = 0.03, OR = 0.12) in patients with SCC when compared with healthy controls. These results indicate that HLA-B*51:01:02 may confer susceptibility to SCC and HLA-B*51:01:01 may contribute to the resistance to the development of SCC in Chinese women. None of the HLA-A-B or HLA-A-B-DRB1 haplotypes were significantly different in cases and controls after multiple testing corrections, implicating those individual allele associations are independent of the identified haplotypes. These results support the hypothesis that some HLA-B alleles could be involved with susceptibility for developing SCC.
Highlights
Cervical cancer is the second most common cancer in women (Armstrong, 2010)
These results indicate that Human leukocyte antigens (HLA)-B*51:01:02 may confer susceptibility to Squamous cell carcinoma (SCC) and HLA-B*51:01:01 may contribute to resistance to the development of SCC
We investigated the associations of HLA-A, -B, and -DRB1 alleles with SCC on 100 SCC patients and 254 healthy control Chinese women
Summary
Cervical cancer is the second most common cancer in women (Armstrong, 2010). In 2010, cervical cancer killed about 200,000 women, of whom 46,000 were aged 15-49 years in developing countries (Forouzanfar et al, 2011). Squamous cell carcinoma (SCC) is the most common type of cervical cancer (Howlader et al, 2013). It develops from the cells that line the inner part of the cervix. Is a necessary cause of cervical cancer. Only a small fraction of affected population progresses into cervical cancer, suggesting that other cofactors are needed for the pathogenesis.
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