HLA適合血小板輸血

Abstract

In seven acute leukemia patients treated with the transfusion of platelets derived from random donors, the mean interval from the beginning of the platelet transfusion to the anti-HLA antibody detection was found to be 2.7 months. HLA-matching platelet transfusions were effective in all of these seven cases, the corrected platelet increment after 24 hours (CPI 24) being 1.27±0.93. In one of them, HLA-matching platelets instead of platelets derived from random donors were necessary, even after the disappearance of his anti-HLA antibody. In this patient of blood type A having received frequent ABO-mismatching platelet transfusions, the CPI 24 of ABO-identical platelet transfusions was compared with that of incompatible transfusion. The CPI 24 of the latter tended to be lower, and furthermore, ABO-incompatible platelet transfusions caused increment of anti-B alloimmunized antibody titer reaching as high as 1: 128,000, thereafter transfusions of AB or B type platelets being ineffective. In such a situation, ABO-identical platelets seemed to be needed.