Abstract
Objective: Fibromyalgia Syndrome [FMS] is a prevalent rheumatic disorder whose etiology and pathogenesis remains largely unknown. Two previous studies have reported familial clustering of FMS cases and patients with history of rheumatism and/or arthritis in first degree relatives. Another study showed the association of HLA-DR4 antigens in FMS patients, a finding not confirmed in subsequent larger studies. The objective of this study was to investigate the possible association of FMS with individual class I [loci A, B and C] and class II [DR] human leukocyte antigen [HLA] antigens. Methods: HLA-typing was determined in fifty-two FMS patients [49 females; mean age 46.7 years ± 8.9]. All FMS patients met the American College of Rheumatology 1990 classification criteria. Patients were compared with a control group of 869 normal individuals. Loci A and B were determined in all the control population, locus C in 832 and locus DR in 344 of those individuals. All loci were studied by National Institutes of Hea...
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