Abstract
HLA, killer cell inhibitory receptors and autoimmune anemia
Highlights
Pure red-cell aplasia (PRCA) is characterized by anemia, reticulocytopenia, and severe erythroid hypoplasia of the bone marrow associated with normal maturation of myeloid and megakaryocytic cell lines
A combination of large granular lymphocyte (LGL) expansion with PRCA may occur in association with rheumatoid arthritis or Felty?s syndrome
Lysis of Daudi cells was greatly diminished by pretreatment with anti-Î1 monoclonal antibodies (mAbs) or antibodies against p58.1, CD94 and p70, but not against other killer cell inhibitory receptors, such as p58.2, which were not expressed on the patient's lymphocytes
Summary
HLA class I, killer inhibitory receptors, large granular lymphocytes, pure red-cell aplasia. Pure red-cell aplasia (PRCA) is characterized by anemia, reticulocytopenia, and severe erythroid hypoplasia of the bone marrow associated with normal maturation of myeloid and megakaryocytic cell lines. A proportion of PRCA is associated with T cell large granular lymphocytic leukemia, chronic lymphocytic leukemia or thymoma. A combination of large granular lymphocyte (LGL) expansion with PRCA may occur in association with rheumatoid arthritis or Felty?s syndrome. The role of expansion of large granular lymphocytes (LGLs), some of which may have a natural killer cell or T cell phenotype, in PRCA is not clear. In a patient with PRCA and expansion of LGLs, that the LGLs are directly involved in the lysis of erythropoietic precursors
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