Abstract
Hla typing at the A and B locus was performed in 13 sibships of juvenile onset diabetics (JOD). Eight families had more than one diabetic sibling. HLA identity was significantly associated with the development of JOD. Fifty-five per cent of the HLA identical index siblings were diabetic. HLA-B8 was significantly increased in the diabetic sibs. There was a significant increase in HLA-A28 and decrease in HLA-B17 in the non-diabetic siblings compared with controls.
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