Abstract
The HLA-DR genotypes of 61 primary colorectal carcinomas obtained from patients of Chinese origin were determined by using DNA-RFLP. No increase or decrease of a particular HLA genotype could be ascertained with the disease, although we detected an antigen frequency of 29.5% for the serologically ill-defined DR“X3” specificity. We identified and sequenced HLA-DRB1 and DRB3 genes from the DR“X3” haplotype. The DR“X3” DRB1 gene was found to be identical to DRB1 ∗1201 (Dr5{w12}). A unique observation is its unusual linkage with DRB3 ∗0101 (DRw52a) or DRB3 ∗0301 (DRw52c) instead of the usual linkage with DRB3 ∗0201/2 (DRw52b). These associations are rare in whites and blacks.
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