Abstract
The observations of HLA-genotyped 13 family cases of Hodgkin's disease including 7 pairs of affected sibs, 4 parent/child cases and 2 pairs of first cousins are reported. Among the pairs of affected sibs, an excess of HLA identical patients ( 6 observed out of 7) ( 1.75 expected) do not reach the level of statistical significance. However when the results are pooled with international data, the increased frequency of HLA identity among the affected sibs reaches a significant level (P < 0.05). This observation strongly supports the hypothesis of the role of the HLA complex as one of the factors of susceptibility to Hodgkin's disease.
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