Abstract
HLA-DR Frequency in Individuals with Rheumatoid Arthritis and Lung Affection
Highlights
Rheumatoid arthritis (RA) is an autoimmune disease whose etiology is unknown, while its immunopathogenesis involves the participation of both genetic and environmental factors
A total of 54 participants (56.0%) exhibited extra-articular manifestations, most frequently subcutaneous nodules (19.0%)
HLA-DRB1*0901 was the allele most frequently found among the participants with lung affection, identified in 50% of them
Summary
Rheumatoid arthritis (RA) is an autoimmune disease whose etiology is unknown, while its immunopathogenesis involves the participation of both genetic and environmental factors. The presence of HLA-DR4 is more strongly associated with aggressive RA, characterized by the progression of radiological erosion, positive rheumatoid factor (RF) and extra-articular manifestations, than with susceptibility to the disease [5,6,7]. Homozygosity for the HLA-DR1 allele with shared epitope, alleles *0401 and *0404, seems to correlate strongly with severe manifestations of the disease, including the presence of subcutaneous nodules, positive RF and radiological erosion [8]. With regard to such findings, it has been suggested that genotyping individuals with RA might afford information relevant to their prognosis [9]. RA can affect any joint, the participation of the metacarpal, metatarsophalangeal, proximal interphalangeal, wrist and knee joints is most frequent and is characterized by swelling, sensitivity on palpation, morning stiffness and severe motion impairment [10]
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