Abstract
ObjectivesTo analyze the role of HLA-DRB1 and -DPB1 alleles in the pathogenesis of neuromyelitis optica (NMO) and multiple sclerosis in Southern Han Chinese. MethodsThirty serum anti-aquaporin 4 antibodies (AQP4-Ab)-positive NMO patients, 53 conventional multiple sclerosis (C-MS) patients, and 93 controls (CTLs) were enrolled. The HLA-DRB1 and -DPB1 alleles of the subjects were determined by sequencing-based typing (SBT). ResultsThe frequency of the DRB1*0901 was lower in NMO patients than in CTLs (Puncorr=0.022, OR: 0.194, 95% CI: 0.043–0.876), and DRB1*1602 was higher in NMO patients than in C-MS (Puncorr=0.038, OR: 3.491, 95% CI: 1.024–11.896) and CTLs (Puncorr=0.051, OR: 2.711, 95% CI: 0.971–7.556). The frequency of DPB1*0501 was significant higher in NMO patients than in C-MS (Puncorr=0.018, OR: 4.629, 95% CI: 1.235–17.350) and CTLs (Puncorr=0.001, Pcorr=0.022, OR: 7.096, 95% CI: 2.011–25.044). ConclusionsDPB1*0501 correlates with risk of AQP4-Ab positive NMO in Southern Han Chinese.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
