Abstract
Immune responses to both HLA donor specific antibody (DSA) as well as lung associated self antigens have been implicated in chronic lung allograft dysfunction (CLAD). Furthermore, several studies have suggested that a bias in the HLA-DR antigens may promote a T-cell driven response to self-antigens. The goal of this study was two-fold; firstly we investigated the association of de novo HLA DSA with bronchiolitis obliterans syndrome (BOS) as well as restrictive allograft syndrome (RAS). Secondly, we investigated the HLA genotypes of both recipients and donors to determine if there was any antigen bias associated with either form of CLAD.
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