Abstract
Immune responses to both HLA donor specific antibody (DSA) as well as lung associated self antigens have been implicated in chronic lung allograft dysfunction (CLAD). Furthermore, several studies have suggested that a bias in the HLA-DR antigens may promote a T-cell driven response to self-antigens. The goal of this study was two-fold; firstly we investigated the association of de novo HLA DSA with bronchiolitis obliterans syndrome (BOS) as well as restrictive allograft syndrome (RAS). Secondly, we investigated the HLA genotypes of both recipients and donors to determine if there was any antigen bias associated with either form of CLAD.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
