HLA class I and II alleles profile in Indian patients with aplastic anemia

Abstract

Several HLA allele associations with aplastic anemia have been reported around the world. However, due to a lack of such association studies in the Indian population, the current study looked at the frequency of HLA class I (A, B, and C loci) and II (DRB1 and DQB1 loci) with aplastic anemia to see if there was an association between the HLA allele and the disease. A total of 49 aplastic anemia patients (cases) and 100 healthy participants (controls) were included in the study. All of these samples were HLA typed for HLA-A, -B, -C, -DRB1, and DQB1 loci using a polymerase chain reaction sequence-specific oligonucleotide probe approach. A positive association of HLA-DRB1*15:02 (p = 0.00001269, OR = 4.275), was found with AA. Whereas HLA-C*07:01 (p = 0.0017318, OR = 0.179) and HLA-DQB1*02:01 (p = 0.00017033, OR = 0.371) were found to be negatively associated. Our findings are the first to show an association between class I and II HLA alleles and aplastic anemia in the Indian population, and they can be used to further investigate aplastic anemia studies.