Abstract
BackgroundHLA antigens have been widely studied for their role in transplantation biology, human diseases and population diversity. The aim of this study was to provide the first profile of HLA class I and class II alleles in the Mauritanian population.MethodsHLA typing was carried in 93 healthy Mauritanian blood donors, using single specific primer amplification (PCR-SSP).ResultsOccurrences of the main HLA class I (-A, -B, -C) and class II (-DR, -DQ) antigens in the general population showed that out of the 17 HLA-A allele groups detected, five main HLA-A allele groups: A*02 (18.42%), A*01 (14.04%), A*23 (14.04%), A*30 (13.16%) and A*29 (12.28%) were the most common identified along other 12 relatively minor allele groups. Twenty three allele groups were observed in the locus B of which B*07 (13.46%) was the most prevalent followed by B*15, B*35, B*08 and B*27 all, with a frequency between 7 to 8%. Three prevalent HLA-C allele groups (C*02: 35.09%, C*07: 20.19% and C*06: 13.6%) were detected. The main HLA class II observed allele groups were: DRB1*13 (27.42%), DRB1*03 (24.73%), DRB1*11 (13.98%), DQB1*03 (36.03%), DQB1*02 (22.06%) and DQB1*05 (18.8%). Except for few haplotype in class I (A*02-B*07: 4.45%, A*02-C02: 10%, A*23-C*02: 8.8%, B*07-C*02: 8.8%, B*15-C*02: 8.8%) and in class II (DRB1*13-DQB1*06: 11.94%, DRB1*03-DQB1*02:11.19% and DRB1*03-DQB1*03: 10.45%), the majority of locus combination were in the range of 2–3%. A single predominant haplotype C*02-DRB1*03 (16.67%) was found.ConclusionsThese results, in agreement with previous data using different tissues markers, underlined the ethnic heterogeneity of the Mauritanian population.
Highlights
Human leucocyte antigen groups (HLA) antigens have been widely studied for their role in transplantation biology, human diseases and population diversity
HLA allele groups in the general population Occurrences of the main HLA class I (−A, -B, -C) and class II (−DR, −DQ) allele groups in the general population (Table 1) showed that out of the 17 HLA-A allele groups detected, A*02 (18.42%) was the most frequent followed sequentially by A*01, A*23, A*30 and A*29 all having a frequency above 12%
A similar pattern was observed in HLA-B with B*07 (13.46%) being the prevalent allele group tailed by B*15, B*35, B*08 and B*27 with frequencies near to 8%
Summary
HLA antigens have been widely studied for their role in transplantation biology, human diseases and population diversity. Matching of the two most known human leucocyte antigen groups i.e. HLA class I and class II is the main immunological barrier to organ transplantation. These two glycoproteins do not have the same cellular distribution and participate in the antigen peptide presentation to the effector cells in two different ways [1], both molecules segregate in the same codominant. The present Mauritanian population consists of two ethnic groups: the Moors (Maures) composed of white and black Moors. This group constitutes about 85% of the general Mauritania population and ethnically selfidentifies with the neighboring North Africa populations. This study provides the first available source on the global frequencies and ethnic distribution of HLA class I and II antigens in the Mauritanian population
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