Abstract
It has been suggested that primary vesicoureteral reflux (VUR) and/or the susceptibility to develop renal damage from VUR might be determined by gene(s) in linkage disequilibrium with the major histocompatibility complex (MHC). To test this hypothesis, we compared the frequencies of HLA antigens in 44 patients with ESRN with those observed in 526 blood donors used as controls (C). The frequencies of the individual antigens, as well as all possible combinations of HLA-A and HLA-B antigens, were studied. HLA-BW15, HLA-B12 and HLA-B8 individually or in combination, tended to occur in higher than normal frequency in ESRN. These results suggest that there is an association between the MHC and a genetic predisposition to develop VUR or renal damage from VUR. This finding might add a new insight into the pathogenesis of reflux nephropathy, since the antigens involved have been found in association with organ specific autoimmune and atopic diseases.
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