Abstract
The histones of 75 human tissues were examined by polyacrylamide gel electrophoresis. A new minor Hl histone called Hl h was found in every case and is proposed to be characteristic of human tissue. The previously described minor Hl histone, Hla, was not detectable in lymph nodes or spleen. The amount of Hl h and Hla relative to the principle Hl band varied from tissue to tissue. As compared to the normal tissue, the amount of Hl h was increased and the Hla decreased in cancers. The sole exception was one hepatocellular carcinoma in which the Hla was increased in the tumor. In two cases of carcinoma of the breast the Hla was decreased to an almost undetectable level. No changes in the other histones were found. These observations may be useful in the diagnosis and prognosis of human malignant disease as well as in forensic medicine.
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