Abstract
HL-A histocompatibility antigen typing has been carried out in 31 women with gestational trophoblastic neoplasms, their husbands, and 50 of 62 offspring in the 26 families in which there are living offspring. In 15 families it was possible to study the child associated with the pregnancy giving rise to the gestational choriocarcinoma. Histocompatibility between the mother and fetus associated with choriocarcinoma, based on HL-A leukocyte antigen specificities, was found in 2 of the 15 families studied, and possible compatibility was found in one other such family. Possible histocompatible matings were found in 5 of the other 16 families studied. This incidence is higher than would be expected in random matings. There was no correlation between compatibility and presence of metastases. Cure by chemotherapy occurred in the presence of compatibility. Failure to respond to chemotherapy occurred in one incompatible mating.
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