HIV-related stigma and substance use in a Russian cohort of HIV+ risky drinkers

Abstract

Drug and Alcohol Dependence 156 (2015) e183–e245 e197 COCduring conditioning, (3) pre-TAUandTAUduring conditioning, and (4) COC during conditioning. Results: Males and females that were not pre-treated with COC showed a significant preference to the COC-paired chamber. Neither male nor female subjects showed a preference to the TAU-paired chamber. Taurine was effective in inhibiting cocaine preference in both male and female subjects after the preTAU; however, females show a significant preference towards the cocaine-paired chamber when TAU and COC are co-administered. Conclusions:Coc-inducedbehaviors oftenpersist for years after abstinence and the best form of treatment is yet to be determined. This study provides evidence that taurine might deserve study as a treatment for cocaine addiction; however, sex may influence its efficacy. Further studies will be performed to assess possible mechanisms by which taurine inhibits cocaine preference, its relationship to gonadal hormones. Financial support: Supported by NIDA R25DA030310 (KSR); NCRR 5G12RR003060-26, NIMHHD 8G12MD7603-27 (EF, KSR); NIH MARC U*STAR 5T34 GM007639-32 (KU); K05DA015799 (J.C. Anthony, sponsor). http://dx.doi.org/10.1016/j.drugalcdep.2015.07.529 HIV-related stigma and substance use in a Russian cohort of HIV+ risky drinkers Jeffrey Samet1,∗, Karsten Lunze1, Debbie M. Cheng1, Dmitry Lioznov3, Emily Quinn1, Carly Bridden1, Christine Chaisson1, Alexander Y. Walley1, E. Krupitsky3, Anita Raj4, E.J. Edelman2 1 Boston University, Boston, MA, United States 2 Yale, New Haven, CT, United States 3 First St. Petersburg Pavlov State Medical U, St. Petersburg, Russian Federation 4 UCSD, San Diego, CA, United States Aims: To determine whether HIV-related stigma contributes to substance use and dependence among HIV+ Russian individuals with risky alcohol use. Methods: We used data from HERMITAGE, a randomized controlled trial of 700 HIV+ individuals with past 6-month risky sex and risky alcohol use in St. Petersburg, Russia (2007–2011). Demographics, clinical and behavioral characteristics were collected by survey at baseline, 6 and 12 months. We measured HIV-related stigma using the abbreviated Berger HIV-related stigma scale. We assessed past 30 day drug use (modified Risk Behavior Scale), risky alcohol use (Timeline Followback), and substance dependence (CIDI short form). Generalized estimating equations were constructed to examine the association between high HIV-related stigma (score >75th percentile) and substance use over time (any prior 30 days heroin or stimulant or risky alcohol use [per NIAAA criteria]). Secondary outcomes were (1) any prior 30 days heroin or stimulant use; (2) prior 30 days risky alcohol use; and (3) past year alcohol or drug dependence. We adjusted for demographics, education, marital status, intervention group, time since HIV diagnosis, depressive symptoms, antiretroviral therapy use, CD4 count, and social support. Results:At baseline, themean agewas 30 (SD 5) years, with 41% women. Twenty-eight percent reported high HIV-related stigma; 87% reported substanceuse in theprior 30days. In adjustedmodels, high HIV-related stigma (AOR=0.86 [95% CI 0.51, 1.45]) was not significantly associated with substance use. These findings were similar for the secondary outcomes. Conclusions: HIV-related stigma does not appear to be associated with substance use among risky drinkers. Future efforts to identify modifiable factors which contribute to substance use among HIV+ individuals with risky alcohol use are needed. Financial support: R01AA016059; K12DA033312; R25DA013582. http://dx.doi.org/10.1016/j.drugalcdep.2015.07.530 Impact of telehealth in-home-messaging devices on alcohol use in dually diagnosed veterans Elizabeth J. Santa Ana1,∗, Steve Martino2, Mulugeta Gebregziabher1 1 Charleston VAMC and Medical University of South Carolina, Charleston, SC, United States 2 Yale University School of Medicine, West Haven, CT,