Abstract
Serological surveys and recording of acquired immunodeficiency syndrome (AIDS) cases have been conducted in Bangui since 1985 to monitor the spread of HIV-1 in the Central African Republic. 2.1% in 1985 3.8% in 1986 and 7.8% of sera in the completed period of 1987 had antibodies to HIV-1--a striking increase. The expected number of new cases of AIDS from January 1986 to March 1987 was calculated to be 734. During that period only 99 cases of AIDS defined by Centers for Disease Control (CDC) criteria were reported to the authors Bangui institute. However 587 cases (including the 99) were recorded using WHO Bangui workshop criteria. Thus the provisional clinical case definition of AIDS developed in Bangui detected 80% of predicted cases compared with only 13.5% when CDC criteria were used. These differences could at least partly explain the small number of AIDS cases reported from certain countries with high HIV seroprevalence rates.
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