Abstract
<h3>To the Editor.</h3> —Incidence of human immunodeficiency virus (HIV) infections in men and women may predict the magnitude of the acquired immunodeficiency syndrome (AIDS) epidemic, to evaluate the efficacy of prevention programs and to design vaccine trials. Surveys of HIV-1 seroincidence in small samples of high-risk women in the United States outside New York City (NYC) have reported annual rates of 3% to 5%.<sup>1,2</sup>Six-month seroincidence among 377 women attending a NYC public clinic for sexually transmitted diseases was 1.7%.<sup>3</sup> We have estimated the HIV seroconversion rate among high-risk, HIV-negative women in NYC as part of the NYC Perinatal HIV Transmission Collaborative Study. Pregnant women at risk for HIV infection (having a history of injection drug use [IDU], crack cocaine use, or sexual exposure to a man with history of IDU) were enrolled at six NYC hospitals between 1986 and 1992 as controls in a prospective study of
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