Abstract
Long and short term side effects of antiretroviral drugs are not fully understood yet. Here a case of reversible blood count changes following post exposure prophylaxis with tenofovir/emtricitabin and lopinavir/ritonavir is reported. We propose that antiretroviral drugs used in post exposure prophylaxis may have a significant impact on hematopoiesis.
Highlights
Needle prick injury is common in clinical practice
We report a case of reversible leukopenia and thrombocytopenia following a 28 days course of post exposure prophylaxis with tenofovir/emtricitabin and lopinavir/ritonavir
After stratification of benefits and risks, no further invasive clarification of pathogenicity was initiated. Cytopenia such as anemia, thrombocytopenia, neutropenia or lymphopenia is a known effect of Human immunodeficiency virus (HIV) and Acquired immunodeficiency syndrome (AIDS) status is an identified risk factor
Summary
Needle prick injury is common in clinical practice. In order to prevent HIV infection, post exposure prophylaxis (PEP) is considered in situations with potential risk of infection [1,2]. In order to prevent HIV infection, post exposure prophylaxis (PEP) is considered in situations with potential risk of infection [1,2]. We report a case of reversible leukopenia and thrombocytopenia following a 28 days course of post exposure prophylaxis with tenofovir/emtricitabin and lopinavir/ritonavir. Case presentation A 56 years old male patient presented after occupational needle prick injury.
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