HIV Nucleic Acid Amplification Testing Versus Rapid Testing

Abstract

We conducted a study comparing the OraQuickADVANCE Rapid HIV-1/2 Antibody Test, Uni-Gold Recombigen HIV Test, Determine HIV 1/2 Ag/Ab Combo, EIA, and pooled nucleic acid amplification testing (NAAT). Men who have sex with men rated tests based on specimen collection method and trust in each test. Among 490 subjects, OraQuick performed on oral fluids ranked highest for specimen collection method but lowest on trust; NAAT scored highest on trust. Among a subset of these subjects, 46% would opt for NAAT if choosing one test. Strategies are needed to increase HIV testing that is accurate and consistent with client preferences.