Abstract
We wish to respond to the editorial comment HIV immune reconstitution syndrome in sub-Saharan Africa by Dr Easterbrook. Although our prospective study suggested that the immune reconstitution inflammatory syndrome (IRIS) may have less impact on antiretroviral treatment (ART) programmes in resource-limited settings than previously suggested by retrospective studies Dr Easterbrook questions whether our experience from Johannesburg is representative for sub-Saharan Africa and whether our study has underestimated the IRIS burden. In order to accurately draw conclusions from our study we wish to clarify a few of our findings. (excerpt)
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