Abstract

Cutaneous and mucosal fungal infections are very common in HIV-infected individuals. Superficial fungal infections or dermatomycoses usually represent overgrowth of fungi that colonize epithelial sites. Invasive cutaneous fungal infections can arise at an epithelial site by extension of focal infection, but more commonly they represent hematogenous dissemination of fungal infection from the lung. The majority of invasive fungal infections occur when latent pulmonary infection such as cryptococcosis is reactivated and is associated with a decline in cell-mediated immunity. In reviewing the literature on mucocutaneous fungal infection in HIV disease, the following factors, which alter the natural history of fungal infection, should be kept in mind:

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