Abstract
In this study 15 banked samples of HIV-related Non-Hodgkin's Lymphoma (NHL) cases were tested for HIV co-receptor usage and SDF1 3'A polymorphism. Reportable tropism from 9 plasma samples had 1 (11.1%) HIV case with CXCR4 and 8 (88.9%) with CCR5 usage, even though most of the cases occurred at a late stage of HIV (2/3 had CD4 counts below 200), where expected CXCR4 usage would be 60%. Based on the expected proportion of less than 50% CCR5 in chronically infected individuals, this would suggest that in NHL may be associated with CCR5 usage (P = 0.04).
Highlights
Active antiretroviral treatment (HAART) has prolonged survival in HIV infected individuals [1], HIV associated malignancies remain relatively common [2]
The chemokine for CXCR4, stromal cell derived factor 1 (SDF1), has been associated with HIV associated Non-Hodgkin’s lymphoma (NHL) when individuals have a polymorphism in the SDF1 gene from G to A transition at position 801 (SDF1-3’A) that increased with homozygosity [14]
We examined whether HIV co-receptor usage and the SDF1 polymorphisms were associated with HIV-related NHL
Summary
Active antiretroviral treatment (HAART) has prolonged survival in HIV infected individuals [1], HIV associated malignancies remain relatively common [2]. The chemokine for CXCR4, stromal cell derived factor 1 (SDF1), has been associated with HIV associated Non-Hodgkin’s lymphoma (NHL) when individuals have a polymorphism in the SDF1 gene from G to A transition at position 801 (SDF1-3’A) that increased with homozygosity [14]. There was some suggestion that SDF1-3’A is associated with HIV disease progression [16], and CXCR4 tropic virus [17]. Based on these observations, we examined whether HIV co-receptor usage and the SDF1 polymorphisms were associated with HIV-related NHL
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