Abstract
Results In HIV infected adults, a significant reduction in nonswitched memory B cells (CD19+IgD+CD27+) was observed, compared to healthy controls (p=0.046). With ongoing viral replication and reduced CD4 count, an expansion in CD21CD27 (tissue like memory) population was observed and the correlation was statistically significant (p=0.0004). The mean frequency of CD21CD27 (resting memory) was significantly higher in controls (p=0.0002) compared to HIV-1 infected adults, while tissue like memory were highly expanded in HIV infected adults compared to controls (p=0.0001). B cells in HIV-1 infected adults expressed higher frequency of CD95 compared to healthy controls (p=0.0004).
Highlights
Progression of HIV-1 infection can be monitored by studying the frequency of B cell subpopulations which could serve as a better surrogate marker
Background Progression of HIV-1 infection can be monitored by studying the frequency of B cell subpopulations
B cells in HIV-1 infected adults are more prone to Fas mediated apoptosis compared to healthy controls
Summary
Ravinder Singh1*, Neema Negi[2], Bimal Kumar Das[2], Rakesh Lodha[1], SK Kabra[1], Madhu Vajpayee[2]. From 2nd International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2014) Chennai, India. From 2nd International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2014) Chennai, India. 30 January - 1 February 2014
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