Abstract
To the Editor: Since the identification of HIV-1 as the primary cause of AIDS, much effort has been made to develop therapies that potently inhibit virus replication. Unfortunately, HIV-1 uses an error-prone replication machinery that allows the virus to rapidly adapt to new conditions. As a consequence, early single-drug therapies failed because of the rapid appearance of drug-resistant virus variants. The simultaneous use of multiple drugs prevents viral escape because mutations are required in multiple drug targets.
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